Join a Research Study

In the past 15 years, estimates of autism prevalence have increased from 1:800 (DSM-IV, APA, 1994) to as high as 1:110 presently (2008, CDC). If as data suggest, most adults have limited prognoses, studying predictors of outcomes among those currently just reaching adulthood can provide an understanding of how to provide positive and cost-effective treatment.

This research study is aimed at better understanding the biological mechanisms underlying autism spectrum disorders. A first step towards this process would be development of an easily and reliably measurable biomarker, which requires an understanding of the common elements underlying ASD biology. In the proposed research, we aim to make rapid progress toward identifying a blood biomarker for autism spectrum disorders.

The AT3 Study is a novel prospective study which will carefully monitor young children who were recently diagnosed with autism and who are undergoing detailed biomedical evaluation and treatment with their regular physician at one of five study sites in the United States.

We are studying the clinical, genetic, and radiographic features of brain malformation disorders to better understand the problems that individuals affected by these disorders are likely to face. The goal of our research is to develop a better understanding of the underlying genetic causes as a foundation for devising better treatments for these groups of patients.

The goal of this project is to convert skin cells from patients with 16p11.2 deletion into neurons and study the growth of these neurons in the lab to understand potential neurodevelopmental effects of this deletion and how they might be corrected.

By investigating the structural and functional brain imaging in a cohort of idiopathic ASD patients who have macrocephaly, we are optimistic that we can establish a link between common biochemical and brain developmental pathways that are disrupted in ASD, and thus, plot a path to targeted treatment.

We want to understand why some RASopathy associated features are different among affected people. In order to study this, we will collect genetic information on RASopathy subjects and their family members. We will use this information to determine if there is a change at genetic locations other than the disease genes that may interact with a Ras-MAPK pathway mutation to contribute to the different risk that we see among subjects for developmental problems, cancer risk, muscle strength, and other features.

The purpose of this study is to find genes related to autism spectrum disorders that might differ in boys and girls.

The purpose of this project is to characterize the clinical and behavior features associated with specific genetic mutations likely to be involved in ASD or other neurodevelopmental disorders. Currently Simons VIP is focused on 16p11.2 deletions and duplications, the most common genetic disorder associated with ASD. The end goal of our project is to develop science-based solutions and targeted treatments to improve the lives of individuals with genetic and developmental differences.

The study will be looking at the effects of subject genetic changes on different types of cells that we can study in the laboratory, all from a small skin sample. We believe that this study will expand our knowledge about RASopathies and hope this knowledge could be used to develop new and better treatments in the future.

The purpose of this study is to look at how boys with attention deficit hyperactivity disorder process sound and touch and whether these sensory differences exist on a neurological level.