related_research

Macrocephaly in Autism

By investigating the structural and functional brain imaging in a cohort of idiopathic ASD patients who have macrocephaly, we are optimistic that we can establish a link between common biochemical and brain developmental pathways that are disrupted in ASD, and thus, plot a path to targeted treatment.

Summary

  • Study director: Elliott Sherr, MD PhD
  • Sponsor: NIH and private foundations and grants
  • Recruiting?: Yes
  • Official study title: Brain Imaging and Cell Signaling: Insights into the Biology of Autism
  • Conditions studied: Autism spectrum disorders with macrocephaly

UCSF STAR Clinic

The UCSF STAR Center for people with autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) is directed by Dr. Young Shin Kim. Our goal at STAR is to lead the way to better understanding, treatment, and promotion of well-being for people with ASD and NDDs. Our services for individuals across the lifespan are conducted by teams of psychiatrists, psychologists, and speech and language therapists.

The UCSF STAR Center for people with autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) is directed by Dr. Young Shin Kim. Our goal at STAR is to lead the way to better understanding, treatment, and promotion of well-being for people with ASD and NDDs. Our services for individuals across the lifespan are conducted by teams of psychiatrists, psychologists, and speech and language therapists.

SNAP Neuro-Gastrointestinal Clinic

The SNAP Neuro Gastrointestinal Clinic is a coordinated effort between the divisions of Child Neurology and Pediatric Gastroenterology. This clinic specializes in the assessment of children on and off the autism spectrum with additional challenges with GI conditions such as diarrhea, constipation and cyclical vomiting. Evaluation at our clinic provides investigation into the underlying cause of your child’s neurodevelopmental and gastrointestinal difference as well as behavioral/educational guidance and basic pharmacologic management.

The SNAP Neuro Gastrointestinal Clinic is a coordinated effort between the divisions of Child Neurology and Pediatric Gastroenterology. The SNAP Neuro-GI Clinic is directed by Drs. Elysa Marco and Sue Rhee. Dr Marco is a child neurologist with training in genetics, cognition and functional imaging, and is active in clinical research in this field. She is joined by Dr. Jessica Litwin, also a cognitive and behavioral child neurologist with an expertise in sleep.

Pediatric Language Clinic

The UCSF Pediatric Language Clinic specializes in the evaluation of children with language difficulties at different stages of development, including young children with speech and language delays and apraxia of speech, and older children who struggle with reading, writing, speaking, and comprehension. We are closely affiliated with the UCSF Dyslexia Center, and we are the primary referral clinic for children suspected to have dyslexia and other language-based learning disabilities.

The UCSF Pediatric Language Clinic specializes in the evaluation of children with language difficulties at different stages of development, including young children with speech and language delays and apraxia of speech, and older children who struggle with reading, writing, speaking and comprehension. We are closely affiliated with the UCSF Dyslexia Center, and we are the primary referral clinic for children suspected to have dyslexia and other language-based learning disabilities.

Developmental Medicine Clinic

The Developmental Medicine Clinic provides a comprehensive approach to care with a multidisciplinary team. Specific services include developmental evaluation, behavior management, medication management, and parent education to address a variety of developmental and behavioral needs facing children, adolescents, and their families. Drs. Tom Boyce, Neal Rojas, and Susanne Martin Herz bring their expertise in Developmental-Behavioral Pediatrics to this clinic. A growing group of psychologists, lead by Neuropsychologist Shannon Lundy, PhD, also guide assessments and therapeutic interventions.

The Developmental Medicine Clinic provides a comprehensive approach to care with a multidisciplinary team. Specific services include developmental evaluation, behavior management, medication management, and parent education to address a variety of developmental and behavioral needs facing children, adolescents, and their families. Drs. Tom Boyce, Neal Rojas, and Susanne Martin Herz bring their expertise in Developmental-Behavioral Pediatrics to this clinic. A growing group of psychologists, lead by Neuropsychologist Shannon Lundy, PhD, also guide assessments and therapeutic interventions.

Published Results

Read the published results from the observational studies and treatment trials completed at the UCSF Pediatric Brain Center’s Sensory Neurodevelopment and Autism Program.

The publications listed on this page are a selection of the articles published by the UCSF Pediatric Brain Center’s Sensory Neurodevelopment and Autism Program. If you wish to look for more, you can search PubMED, which is maintained by the National Library of Medicine.

Agenesis of the Corpus Callosum

Autism Trial with RG7314

This multi-center, randomized, double-blind, parallel group, placebo-controlled, proof of concept study will investigate the efficacy and safety of RG7314, a vasopressin 1a (V1a) receptor antagonist, in adult patients with autism spectrum disorders.

Summary

  • Study director: Robert Hendren, DO
  • Sponsor: Hoffman-La Roche
  • Recruiting?: Yes
  • Official study title: A Multi-center, Randomized, Double-blind, 12-week, Parallel Group, Placebo-controlled Proof of Concept Study to Investigate the Efficacy and Safety of RG7314 in Individuals With Autism Spectrum Disorders (ASD)
  • ClinicalTrials.gov identifier: NCT01793441
  • Conditions studied: Autistic disorder

Autism Translation to Treatments Project

The AT3 Study is a novel prospective study which will carefully monitor young children who were recently diagnosed with autism and who are undergoing detailed biomedical evaluation and treatment with their regular physician at one of five study sites in the United States.

Summary

  • Study director: Robert Hendren, DO
  • Sponsor: Private Foundation: Jane Johnson Foundation
  • Recruiting?: Yes
  • Official study title: Autism Translation to Treatments (AT3) Project
  • Conditions studied: Autistic disorder

Autism Trial with Lurasidone

The purpose of this trial is to evaluate the efficacy and safety of two fixed doses of lurasidone (20 mg/day and 60 mg/day) for 6 weeks compared with placebo in pediatric and adolescent subjects with irritability associated with autistic disorder who reside in the community setting.

Summary

  • Study director: Robert Hendren, DO
  • Sponsor: Sunovion
  • Recruiting?: No
  • Official study title: A 6-Week Randomized, Parallel, Double-Blind, Placebo Controlled, Fixed-Dose, Multicenter Study to Evaluate the Efficacy and Safety of Lurasidone in Children and Adolescent Subjects with Irritability Associated with Autistic Disorder
  • ClinicalTrials.gov identifier: NCT01911442
  • Conditions studied: Autistic disorder
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