related_research

ASD Biomarker Study

This research study is aimed at better understanding the biological mechanisms underlying autism spectrum disorders. A first step towards this process would be development of an easily and reliably measurable biomarker, which requires an understanding of the common elements underlying ASD biology. In the proposed research, we aim to make rapid progress toward identifying a blood biomarker for autism spectrum disorders.

Summary

  • Study director: Elliott Sherr, MD PhD
  • Sponsor: NIH and private foundations and grants
  • Recruiting?: Yes
  • Official study title: Biomarker Discovery in Autism Spectrum Disorder (ASD)
  • Conditions studied: Autism spectrum disorders that have been clinically diagnosed

Multi-disciplinary Assessment Center (MDAC) at San Francisco General Hospital (SFGH)

The UCSF Multi-Disciplinary Assessment Center (MDAC) at San Francisco General Hospital provides family-centered assessment services, diagnosis, service linkage, short-term intervention and case management to children and families needing neurological, psychological and medical assessment for suspected or actual developmental delay. MDAC is supported by First5 San Francisco.

The UCSF Multi-Disciplinary Assessment Center (MDAC) at San Francisco General Hospital provides family-centered assessment services, diagnosis, service linkage, short-term intervention and case management to children and families needing neurological, psychological and medical assessment for suspected or actual developmental delay. MDAC is supported by First5 San Francisco.

SNAP Contact Form

The UCSF Pediatric Brain Center’s Sensory Neurodevelopment and Autism Program is committed to conducting new and relevant research. We frequently begin new studies that you or your child might be eligible for. This SNAP Contact Form allows us to keep you informed of new studies through email, phone and periodic newsletters.

The UCSF Pediatric Brain Center’s Sensory Neurodevelopment and Autism Program is committed to conducting new and relevant research. We frequently begin new studies that you or your child might be eligible for. This SNAP Contact Form allows us to keep you informed of new studies through email, phone and periodic newsletters. You may also contact Annie Brandes-Aitken at Anne.Brandes-Aitken@ucsf.edu for more information.

Autism Trial with Vitamin D

The study is a 12-week, open-label trial examining the tolerability of Vitamin D replacement in children with autism spectrum disorders. The study will evaluate whether Vitamin D replacement at high doses will show improvement in the core symptoms of autism, including sociability, eye contact, anger outbursts, stimming behavior, and sleep.

Summary

  • Study director: Robert Hendren, DO
  • Sponsor: Ddrops
  • Recruiting?: No
  • Official study title: Open Label Clinical trial of Vitamin D3 Dosage Tolerability and Effect on Behavioral Measures in Children with Autism
  • ClinicalTrials.gov identifier: Pending
  • Conditions studied: Autistic disorder
  • Intervention: Vitamin D3 (cholecalciferol)
  • Phase: Phase II

Adult Outcomes in Autism

In the past 15 years, estimates of autism prevalence have increased from 1:800 (DSM-IV, APA, 1994) to as high as 1:110 presently (2008, CDC). If as data suggest, most adults have limited prognoses, studying predictors of outcomes among those currently just reaching adulthood can provide an understanding of how to provide positive and cost-effective treatment.

Summary

  • Study director: Bryna Siegel, PhD
  • Sponsor: UCSF
  • Recruiting?: Yes
  • Official study title: Early Childhood Predictors of Adult Outcomes in Autism
  • Conditions studied: Adults who were diagnosed with an autism spectrum disorder before the age of 4 at the UCSF Autism Clinic

JumpStart Learning to Learn

The purpose of the study is to evaluate child and parent outcomes after participation in the treatment program JumpStart Learning-to-Learn (JSLTL). JSLTL is a new approach to early intervention for autism, best characterized as a "first intervention" consisting of an intensive, full-time week of parent and child trainings.

Summary

  • Study director: Bryna Siegel, PhD
  • Sponsor: Flora Foundation
  • Recruiting?: Yes
  • Official study title: Outcomes of JumpStart Learning to Learn
  • Conditions studied: Families with children recently diagnosed with autism who have participated in an intensive early intervention parent training program (JumpStart Learning to Learn)
  • Intervention: JumpStart Learning-to-Learn (JSLTL)

Skin Cell to Stem Cell RasCal Study

The study will be looking at the effects of subject genetic changes on different types of cells that we can study in the laboratory, all from a small skin sample. We believe that this study will expand our knowledge about RASopathies and hope this knowledge could be used to develop new and better treatments in the future.

Summary

  • Study director: Lauren A. Weiss, PhD
  • Sponsor: NIH
  • Recruiting?: Yes
  • Official study title: Skin cell to stem cell RasCal study
  • Conditions studied: RASopathies (a class of developmental syndromes caused by mutations in genes that encode protein components of the Ras/MAPK signaling pathway, such as neurofibromatosis, Costello syndrome, cardio-facio-cutaneous syndrome, and Noonan syndrome)

RASopathy Associated Traits California (RasCal) Study

We want to understand why some RASopathy associated features are different among affected people. In order to study this, we will collect genetic information on RASopathy subjects and their family members. We will use this information to determine if there is a change at genetic locations other than the disease genes that may interact with a Ras-MAPK pathway mutation to contribute to the different risk that we see among subjects for developmental problems, cancer risk, muscle strength, and other features.

Summary

  • Study director: Lauren A. Weiss, PhD
  • Sponsor: NIH
  • Recruiting?: Yes
  • Official study title: RASopathy Associated Traits California (RasCal) study
  • Conditions studied: RASopathies (a class of developmental syndromes caused by mutations in genes that encode protein components of the Ras/MAPK signaling pathway, such as neurofibromatosis, Costello syndrome, cardio-facio-cutaneous syndrome, and Noonan syndrome)

Brain Development Research Program Study

We are studying the clinical, genetic, and radiographic features of brain malformation disorders to better understand the problems that individuals affected by these disorders are likely to face. The goal of our research is to develop a better understanding of the underlying genetic causes as a foundation for devising better treatments for these groups of patients.

Summary

  • Study director: Elliott Sherr, MD PhD
  • Sponsor: NIH and private foundations and grants
  • Recruiting?: Yes
  • Official study title: Brain Development Research Program
  • Conditions studied: Disorders of brain development that are visible on an MRI (or other imaging study) and/or disorders of brain development that have been clinically diagnosed, such as autism, epilepsy or cerebral palsy.
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